Thermo Fisher Scientific QKI Monoclonal Antibody (N147/6), APC
Thermo Fisher QKI Monoclonal Antibody (N147/6), APC은 인간, 마우스, 랫트 QKI 단백질을 검출하는 고특이적 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며 APC 형광 표지로 651/660 nm 파장에서 검출됩니다. 단백질 G 정제, 무보존제, 4°C 보관.
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Applications
- Western Blot (WB): 1:1,000
- Immunohistochemistry (IHC): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N147/6 |
| Immunogen | Fusion protein amino acids 1–341 (full-length) of human QKI-5 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932143 |
Additional Formats
- Unconjugated (MA5-27651)
- FITC (MA5-45690)
- PE (MA5-45692)
- PerCP (MA5-45691)
- Request custom conjugation
Product Specific Information
- Mouse: 100% identity (341/341 amino acids identical)
- Rat: 99% identity (339/341 amino acids identical)
90% identity with QKI-6, QKI-7, and QKI-7b
- 1 µg/mL of MA5-45689 detects Pan-QKI in 20 µg of rat brain lysate by colorimetric immunoblot using Goat anti-mouse IgG:HRP as secondary antibody
- Detects approximately 36–38 kDa
- Formerly sold as clone S147-6
Target Information
This gene encodes the sacsin protein, containing UbL, DnaJ, and HEPN domains. It is highly expressed in the central nervous system, also found in skin, skeletal muscle, and pancreas. Mutations cause autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder with cerebellar ataxia and spasticity. Sacsin protects against mutant ataxin-1. A pseudogene exists on chromosome 11. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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