Thermo Fisher Scientific CaMKII Pan Recombinant Rabbit Monoclonal Antibody (SU03-57)
CaMKII 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF에 사용 가능. HEK293 발현 시스템에서 생산되며 높은 특이성과 일관성을 제공. 단백질 A로 정제된 액상 형태, 연구용으로 적합.
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Thermo Fisher Scientific CaMKII Pan Recombinant Rabbit Monoclonal Antibody (SU03-57)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SU03-57 |
| Immunogen | Synthetic peptide within Human CaMKII aa 201–250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2809416 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Ca2+/calmodulin-dependent protein kinases (CaM kinases) form a subfamily of serine/threonine kinases including CaMKI, CaMKII, and CaMKIV.
CaMKII is an ubiquitously expressed kinase activated by Ca2+/calmodulin binding and autophosphorylation. It regulates cell cycle and transcription, contributes to dendritic spine and synapse formation, neuronal plasticity, and sarcoplasmic reticulum Ca2+ transport in skeletal muscle.
In neurons, CaMKII plays a structural role in actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments independently of kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: MA5-32125_CaMKII_Pan_Q13554-1_Rabbit.svg, MA5-32125_CaMKII_Pan_Q13554-1_Rabbit_PDP.jpeg, MA5-32125_CaMKII_Pan_Q9UQM7-1_Rabbit.svg, MA5-32125_CaMKII_Pan_Q9UQM7-1_Rabbit_PDP.jpeg, MA5-32125_CaMKII_Pan_Q13555-1_Rabbit.svg, MA5-32125_CaMKII_Pan_Q13555-1_Rabbit_PDP.jpeg, MA5-32125_CaMKII_Pan_Q13557-1_Rabbit.svg, MA5-32125_CaMKII_Pan_Q13557-1_Rabbit_PDP.jpeg)
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