Thermo Fisher Scientific SCN9A Polyclonal Antibody
SCN9A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, 인간 시료에 반응합니다. IHC(P)에서 10 µg/mL 농도로 사용되며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며 SCN9A/Nav1.7 단백질 연구에 적합합니다.
- 카탈로그번호
- PA534191
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SCN9A Polyclonal Antibody
Thermo Fisher Scientific SCN9A Polyclonal Antibody
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from internal region of human SCN9A / Nav1.7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551544 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Mouse, Panda, Dog, Bovine, Horse, Rabbit, Pig (94%).
Target Information
Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural similarity, including two short intracellular amino and carboxyl termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous isoforms of the ENaC protein (alpha, beta, and gamma). ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance and mediates aldosterone-dependent sodium reabsorption in the distal nephron, thus regulating blood pressure.
ENaC is thought to be regulated through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.