Thermo Fisher Scientific SCN9A Polyclonal Antibody

Thermo Fisher Scientific SCN9A Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) [IHC (P)]: 10 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Mouse, Panda, Dog, Bovine, Horse, Rabbit, Pig (94%).

Target Information

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural similarity, including two short intracellular amino and carboxyl termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous isoforms of the ENaC protein (alpha, beta, and gamma). ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance and mediates aldosterone-dependent sodium reabsorption in the distal nephron, thus regulating blood pressure.
ENaC is thought to be regulated through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.