Thermo Fisher Scientific Phospho-STAT6 (Tyr641) Recombinant Rabbit Monoclonal Antibody (46H1L12)
Phospho-STAT6 (Tyr641) 항체로 인간 및 마우스 시료에서 STAT6 인산화 상태 분석에 적합. Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. 재조합 래빗 단일클론 항체로 높은 특이성과 재현성 제공. 동물 유래 성분이 없는 포뮬레이션.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 3 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | – |
| Immunocytochemistry (ICC/IF) | 2–4 µg | – |
| ELISA | 1–5 µg/mL | – |
| ChIP assay (ChIP) | 3 µg | – |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 46H1L12 |
| Immunogen | Peptide corresponding to amino acids 636–645 of STAT6 (UniProt ID: P42226) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_10562728 |
Product Specific Information
- Predicted to react with Rhesus monkey, orangutan, bovine, canine, mouse, and rat based on sequence homology.
- Intact IgG appears as ~150 kDa band (non-reducing gel) and upon reduction yields ~25 kDa light chain and ~50 kDa heavy chain.
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA from immunoreactive rabbits.
- Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
STAT6 is a transcription factor activated by cytokines, especially IL-4 and IL-13. STAT6-deficient cells show impaired IL-4-mediated functions such as Th2 differentiation, expression of surface markers, T-cell proliferation, and IgE class switching.
STAT6 mRNA is expressed in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta.
STAT6 plays a critical role in Th2 immune responses and IL-4-mediated biological processes, existing in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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