Thermo Fisher Scientific beta Amyloid Recombinant Rabbit Monoclonal Antibody (H31L21)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Cross-reactivity to Abeta [1–40] is not observed in sandwich ELISA. In antigen ELISA, cross-reactivity is not observed with Abeta [1–37], Abeta [1–38], Abeta [1–40], or Abeta [1–43] when used at low antibody concentrations (up to 30 ng/mL).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.

Advantages:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to rabbit immune repertoire

Target Information

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals with Alzheimer’s disease. Abeta peptide (40–43 amino acids) is generated from beta-amyloid precursor protein (beta APP) through sequential cleavage by beta-secretase (BACE) and gamma-secretase.

Gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, processes the membrane-bound remnant of beta APP to generate Abeta. Nicastrin, associated with presenilins, binds to the carboxyl-terminus of beta APP and modulates Abeta production.

Abeta is a filamentous extracellular protein found in amyloid cores, neuritic plaques, and neurofibrillary tangles. Abnormal beta amyloid deposits are characteristic of Alzheimer’s disease and have also been detected in Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.