Thermo Fisher Scientific ICAM-3 Monoclonal Antibody (MEM-171), PE
인간 ICAM-3(CD50)을 인식하는 Mouse IgG1 단클론 항체로 PE 형광 표지. Flow Cytometry에 최적화되어 있으며, 세포 표면 ICAM-3 발현 분석에 활용 가능. 4°C 암소 보관, 동결 금지.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-171 |
| Immunogen | Human granulocytes |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152541 |
Additional Formats
- Unconjugated (MA1-19191)
- Alexa Fluor 488 (MA5-18145)
- Biotin (MA1-19508)
- Request custom conjugation available
Product Specific Information
This antibody recognizes an extracellular epitope in the D2 domain of CD50 (ICAM-3), a 120–130 kDa type I membrane protein belonging to the immunoglobulin supergene family. It is expressed on leukocytes, endothelial cells, and Langerhans cells, but not on platelets or erythrocytes.
Target Information
CD50 (ICAM-3) is a transmembrane glycoprotein expressed by leukocytes and serves as a counter-receptor for the LFA-1 integrin. It mediates adhesion between T cells and antigen-presenting cells, regulates LFA-1 affinity for ICAM-1, and induces T cell activation and proliferation. ICAM-3 plays a key role in initiating immune responses and interacts with CD209 (DC-SIGN), facilitating communication between dendritic cells and granulocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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