Thermo Fisher Scientific Phospho-FGFR1 (Tyr653, Tyr654) Polyclonal Antibody
FGFR1의 Tyr653/654 인산화를 인식하는 Rabbit Polyclonal 항체. Human, Mouse, Rat 반응성. Western blot에 적합하며 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide corresponding to residues around human FGFR1 (phospho Tyr653/654) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.99 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792942 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%), Japanese Medaka (100%), Xenopus laevis (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%).
- Positive Control: U87-MG, NIH-3T3, C2C12, Rat2.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that includes four membrane-spanning tyrosine kinases (FGFR1–4) serving as high-affinity receptors for FGF1–17.
The FGF receptor family is involved in key biological processes such as mesoderm induction, cell growth and migration, organ formation, and bone growth.
FGFR1 undergoes alternative splicing, producing multiple variants expressed differently during development and in adults.
Mutations or aberrations in FGFR1 are linked to several disorders, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal rearrangements involving FGFR1 are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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