Thermo Fisher Scientific CD21 (Mature B-Cell and Follicular Dendritic Cell Marker) Recombinant Rabbit Monoclonal Antibody (CR2/3990R)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

CR2/3990R

Immunogen

Synthetic peptide corresponding to CD21 residues within aa933-C terminal of CD21. The antigen corresponds to amino acid range 933-1033 of the target protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD21,uniProtId:P20023-1,ncbiNodeId:9606,antigenRange:933-1033,antigenLength:1033,antigenImageFileName:1380-RBM12-P1_CD21_P20023-1_Rabbit.svg,antigenImageFileNamePDP:1380-RBM12-P1_CD21_P20023-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Antibody is stable for 24 months.

Positive Control: Human tonsil tissue. Cellular Localization: Cell Surface

Specificity Comments: CD21 also known as complement C3d receptor, Epstein-Barr virus receptor, and complement receptor type 2 (CR2), is a protein that in humans is encoded by the CR2 gene. This protein is involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d. B cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation.It is expressed by follicular dendritic cells (FDC) and mature B cells, as well as by several types of epithelial cells. CD21 is useful in the identification of follicular dendritic cell matrix found in normal lymph node and tonsillar tissue, and also useful in identifying abnormal.

Target Information

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively, spliced transcript variants encoding different isoforms of CD21 have been found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.