Thermo Fisher Scientific GFAP Polyclonal Antibody
GFAP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. 다양한 종에서 반응하며 WB, IHC, ICC 등 여러 응용에 적합합니다. 액상 형태로 제공되며, 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000 | 4 publications |
| Immunohistochemistry (IHC) | - | 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000 | - |
| Immunohistochemistry - Free Floating (IHC (Free)) | 1:5,000 | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:1,000–1:5,000 | 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rabbit, Rat, Bovine, Chicken, Horse, Guinea pig |
| Published Species | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length human GFAP isotype 1 expressed in and purified from E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 5 mM sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2109795 |
Product Specific Information
This antibody is likely to react with most mammals.
Target Information
GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. It is heavily expressed in astrocytes and certain astroglia of the central nervous system, satellite cells of peripheral ganglia, and non-myelinating Schwann cells. Neural stem cells also strongly express GFAP.
Antibodies to GFAP serve as markers for astrocytic cells and are useful in identifying brain tumors derived from astrocytes. GFAP expression is also found in lens epithelium, Kupffer cells, salivary tumors, and erythrocytes.
GFAP helps distinguish astrocytes from other glial cells during development. Mutations in the GFAP gene cause Alexander disease, a rare astrocytic disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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