Thermo Fisher Scientific CADM1 Polyclonal Antibody
Thermo Fisher Scientific의 CADM1 Polyclonal Antibody는 인간 및 랫트에서 반응하며, 웨스턴 블롯 및 면역세포화학에 적합합니다. 비결합형 액상 항체로, 전체 혈청 기반 버퍼에 저장되며 0.02% sodium azide를 포함합니다. CADM1 단백질 연구 및 종양 억제 관련 연구에 활용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 3 publications |
| Immunocytochemistry (ICC/IF) | 1:2,000 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminal region of the rat protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2121871 |
Product Specific Information
Suggested positive control: rat brain.
Target Information
CADM1 mediates homophilic cell-cell adhesion in a Ca²⁺-independent manner and heterophilic adhesion with CADM3 and PVRL3. It acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes NK cell cytotoxicity and IFN-γ secretion by CD8⁺ cells, as well as NK cell-mediated rejection of CADM3-expressing tumors. CADM1 may contribute to less invasive phenotypes of lepidic growth tumor cells and facilitate communication between mast cells and nerves. Together with MITF, it is essential for mast cell development and survival. In neurons, CADM1 functions as a synaptic adhesion molecule involved in synapse assembly, neuronal migration, axon growth, and fasciculation. It also plays roles in spermatogenesis, aiding adhesion of spermatocytes and spermatids to Sertoli cells for proper differentiation into mature spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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