Thermo Fisher Scientific MEK1 Recombinant Rabbit Monoclonal Antibody (3F10)
MEK1 단백질을 인식하는 토끼 단클론 항체로, Western blot, IHC, IP 등 다양한 응용에 적합합니다. 고순도 정제 및 높은 특이성을 제공하며, 인간 MEK1에서 유래한 합성 펩타이드로 면역화되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1:200–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3F10 |
| Immunogen | A synthesized peptide derived from human MEK1 (amino acids 214–233, UniProt ID: Q02750-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.72 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898235 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. MEK1 is activated by phosphorylation of serine 218 and 222 residues by Raf1. It is known to be involved in signaling during stress-activated response, apoptosis, and proliferative induction by cytokines. Mutations in the gene can lead to cardiofaciocutaneous syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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