Thermo Fisher Scientific HSPA1L Monoclonal Antibody (OTI3B5), TrueMAB
HSPA1L 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI3B5). Western blot에 적합하며, 인간 시료에 반응. 고순도 Affinity chromatography 정제, PBS/BSA/glycerol buffer에 저장. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 400–641 of human HSPA1L produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
In response to environmental stress, cells increase expression of heat shock proteins (HSPs). The small heat shock proteins (15–30 kDa) are diverse, with single forms in yeast and humans, and multiple forms in higher plants. Elevated stress protein expression has been linked to neoplasia, particularly in estrogen-induced proteins in breast cancer cells. Hsp27 shows rapid phosphorylation upon exposure to mitogens, tumor promoters (e.g., phorbol esters), and calcium ionophores. Expression of a 24 kDa estrogen-induced protein correlates with steroid hormone receptor presence and is highly expressed in breast carcinoma. Hsp27 levels have also been associated with endometrial adenocarcinomas. Regulation of human Hsp27 by estrogens and heat shock resembles ecdysteroid and heat shock activation of Drosophila Hsp20 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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