Thermo Fisher Scientific OPTN Monoclonal Antibody (OTI7H2), TrueMAB
OPTN 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(P) 실험에 적합. HEK293T 세포에서 발현된 인간 OPTN 재조합 단백질로 면역화. 액상 형태, 1 mg/mL 농도, 친화 크로마토그래피로 정제됨. 연구용 한정 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7H2 |
| Immunogen | Full length human recombinant protein of human OPTN produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes the coiled-coil containing protein optineurin (OPTN).
Optineurin may play a role in normal-tension glaucoma and adult-onset primary open-angle glaucoma.
It interacts with adenovirus E3-14.7K protein and may utilize TNF-α or Fas-ligand pathways to mediate apoptosis, inflammation, or vasoconstriction.
Additionally, optineurin may function in cellular morphogenesis, membrane and vesicle trafficking, and transcription activation through interactions with RAB8, huntingtin, and transcription factor IIIA proteins.
Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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