Thermo Fisher Scientific Amyloid Precursor Protein Polyclonal Antibody
Thermo Fisher Scientific의 Amyloid Precursor Protein Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 Western blot 및 ICC/IF에 적합합니다. C-말단 합성 펩타이드로부터 유래된 토끼 폴리클로날 항체로, Alzheimer’s disease 연구에 유용합니다.
- 카탈로그번호
- PA14648
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal region of rat APP conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_557599 |
Product Specific Information
- Predicted to react with canine, chicken, human, mouse, and non-human primate based on 100% sequence homology.
- Specific for ~115 kDa APP protein.
- Immunolabeling of the APP protein band is completely blocked by preadsorption with the immunizing peptide.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide (40–43 amino acids) is generated from the beta-amyloid precursor protein (beta APP) through sequential cleavage by beta-secretase (BACE) and gamma-secretase.
Gamma-secretase is a multi-subunit complex including presenilin-1 and -2, and nicastrin, which modulates APP processing.
Abeta accumulates in amyloid cores, neuritic plaques, and neurofibrillary tangles, characteristic of Alzheimer’s disease and related disorders such as Lewy body dementia, Down’s syndrome, and cerebral amyloid angiopathy.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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