Thermo Fisher Scientific Human GM-CSF Recombinant Protein

Applications

Western Blot (WB)

• Assay-dependent

Immunohistochemistry (IHC)

• Assay-dependent

ELISA

• Assay-dependent

Functional Assay

• Assay-dependent
• View 5 publications

Control

• Assay-dependent

Product Specifications

Product Specific Information

Carrier-Free

• Reconstitution:
  Centrifuge the vial briefly before opening to bring the contents to the bottom.
  Reconstitute the lyophilized protein in sterile, distilled water to 0.1–1.0 mg/mL to regain full activity.
  Apportion the reconstituted protein into working aliquots and store at ≤ -20°C.
  Make further dilutions in medium or buffered solution containing carrier protein (e.g., PBS with 0.1% BSA).

• Storage:
  Store the lyophilized protein at 2–8°C, preferably desiccated.
  Upon reconstitution, apportion into working aliquots and store at ≤ -20°C (not in a frost-free freezer).
  Avoid repeated freeze-thaw cycles.

Target Information

The GM-CSF gene encodes a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes.
The active form of the protein exists as a homodimer in the extracellular space.
This gene is located in a cluster of related genes on chromosome region 5q31, associated with 5q- syndrome and acute myelogenous leukemia.
Other genes in this cluster include IL-4, IL-5, and IL-13.
The gene promotes tissue inflammation, and elevated cytokine levels have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome.
Mice lacking this gene or its receptor develop pulmonary alveolar proteinosis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.