Thermo Fisher Scientific FOLH1/PSMA (Prostate Epithelial Marker) Monoclonal Antibody (FOLH1/2354)
전립선 상피세포 마커인 FOLH1/PSMA를 인식하는 마우스 단클론 항체로, Western blot 및 면역조직화학(IHC)에 사용 가능. 인간, 개, 말, 고양이 반응성 보유. 단백질 A/G로 정제된 액상 형태이며 4°C 보관. 연구용으로만 사용.
- 카탈로그번호
- 2346-MSM2-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific FOLH1/PSMA (Prostate Epithelial Marker) Monoclonal Antibody (FOLH1/2354)
Thermo Fisher Scientific FOLH1/PSMA (Prostate Epithelial Marker) Monoclonal Antibody (FOLH1/2354)
Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL | |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Dog, Horse, Cat, Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FOLH1/2354 |
| Immunogen | Recombinant human FOLH1 protein fragment (around aa 232–433) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including folate and the neuropeptide N-acetyl-L-aspartyl-L-glutamate. It is expressed in tissues such as the prostate, central and peripheral nervous system, and kidney.
A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and hyperhomocysteinemia. Expression in the brain may be involved in pathological conditions associated with glutamate excitotoxicity. In the prostate, the protein is up-regulated in cancerous cells and serves as a diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region, and alternative splicing gives rise to multiple transcript variants encoding several isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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