Thermo Fisher Scientific FOLH1/PSMA Monoclonal Antibody (FOLH1, 3734)
FOLH1/PSMA 단백질을 인식하는 Mouse monoclonal antibody로, WB 및 IHC(P) 등 다양한 응용에 적합. Human 등 여러 종에 반응하며, Protein A/G로 정제된 액상 형태. 연구용으로만 사용 가능.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Horse, Cat, Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FOLH1, 3734 |
| Immunogen | Recombinant fragment (aa 44–177) of human FOLH1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed):
Incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C followed by cooling at room temperature for 20 minutes.
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family.
The protein acts as a glutamate carboxypeptidase on different substrates, including folate and N-acetyl-L-aspartyl-L-glutamate.
It is expressed in prostate, central and peripheral nervous system, and kidney.
Mutations may cause impaired intestinal absorption of folates, leading to low blood folate and hyperhomocysteinemia.
In the prostate, the protein is up-regulated in cancerous cells and serves as a diagnostic and prognostic marker for prostate cancer.
Alternative splicing yields multiple transcript variants encoding several isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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