Thermo Fisher Scientific FOLH1/PSMA Monoclonal Antibody (FOLH1, 2363)
FOLH1/PSMA 단일클론 항체로 Western blot, IHC, Peptide array에 사용 가능. 인간, 개, 소, 랫드 반응성. 비결합형 액상 항체로 Protein A/G 정제. 프로스타트암 진단 연구용으로 적합.
- 카탈로그번호
- 2346-MSM3-P1
- 판매단위
- pk
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Thermo Fisher Scientific FOLH1/PSMA Monoclonal Antibody (FOLH1, 2363)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Rat |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FOLH1, 2363 |
| Immunogen | Recombinant human FOLH1 protein fragment (around aa 232–433) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on various substrates, including folate and the neuropeptide N-acetyl-L-aspartyl-L-glutamate. It is expressed in tissues such as the prostate, central and peripheral nervous systems, and kidney.
Mutations may lead to impaired intestinal folate absorption and hyperhomocysteinemia. Expression in the brain is linked to pathological conditions involving glutamate excitotoxicity. In prostate tissue, this protein is upregulated in cancerous cells and serves as a diagnostic and prognostic indicator of prostate cancer.
This gene likely arose from a duplication event, and alternative splicing produces multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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