Thermo Fisher Scientific PDGFRA Recombinant Rabbit Monoclonal Antibody (7H13L1)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generates a ~25 kDa light chain and a ~50 kDa heavy chain.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits.
• Advantages include:
  • Enhanced specificity and sensitivity
  • Lot-to-lot consistency
  • Animal origin-free formulation
  • Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

PDGFRA is a cell surface receptor tyrosine kinase that binds members of the platelet-derived growth factor family. These growth factors act as mitogens for mesenchymal cells. The receptor composition (homodimer or heterodimer with PDGFRB) depends on the bound ligand. Studies in knockout mice indicate PDGFRA’s essential role in kidney development, as heterozygous mice exhibit kidney defects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.