Thermo Fisher Scientific beta Catenin Recombinant Rabbit Monoclonal Antibody (SA30-04)
Recombinant rabbit monoclonal antibody recognizing beta-Catenin (SA30-04). Validated for WB, IHC-P, and ICC/IF. Reacts with human, mouse, and rat. Supplied as liquid at 1 mg/mL, purified by Protein A, stored at 4°C or -20°C. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:20–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SA30-04 |
| Immunogen | Synthetic peptide within human Beta-Catenin (aa 30–70) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898843 |
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and signaling. It interacts with E-cadherin and alpha-catenin to link adhesion complexes to the actin cytoskeleton. Beta-catenin also associates with the adenomatous polyposis coli protein and participates in Wnt/Wingless signaling pathways. It regulates morphogenesis and is expressed in various epithelial and follicular cells. Abnormal beta-catenin activity has been implicated in pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors. In the nucleus, it co-activates Lef/Tcf transcription factors, promoting expression of genes such as cyclin D and c-myc that drive cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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