Thermo Fisher Scientific Factor VII Polyclonal Antibody
마우스 유래 응고 인자 VII을 인식하는 염소 폴리클로날 항체. Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제, 동결건조 형태로 제공. 교차 반응성이 낮고 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunoprecipitation (IP) | 25 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CHO-derived recombinant mouse Coagulation Factor VII (Ala42–Leu446) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608292 |
Product Specific Information
- In direct ELISAs, less than 5% cross-reactivity with recombinant human Factor VII, Factor X, and Factor Xa is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Coagulation factor VII is a vitamin K-dependent protein essential for hemostasis. It circulates in the blood as a zymogen and is activated by factor IXa, Xa, XIIa, or thrombin through limited proteolysis. Upon activation, it forms a heavy chain (catalytic domain) and a light chain (two EGF-like domains) linked by a disulfide bond. In the presence of factor III and calcium ions, activated factor VII further activates the coagulation cascade by converting factor IX to IXa and factor X to Xa. Defects in F7 production can lead to coagulopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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