Thermo Fisher Scientific CASQ2 Monoclonal Antibody (1B6)

Thermo Fisher Scientific CASQ2 Monoclonal Antibody (1B6)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
EEGLNFPTYD GKDRVVSLSE KNFKQVLKKY DLLCLYYHEP VSSDKVTQKQ FQLKEIVLEL VAQVLEHKAI GFVMVDAKKE AKLAKKLGFD EEGSLYILKG DRTIEFDGEF AADVLVEFLL DLIEDPVEII SSKLEVQAFE RIEDYIKLIG FFKSEDSEYY KAFEEAAEHF QPYIKFFATF DKGVAKKLSL KMNEVDFYEP FMDEPIAIPN KPYTEEELVE FVKEHQRPTL RRLRPEEMFE TWEDDLNGIH IVAFAEKSDP DGYEFLEILK QVARDNTDNP DLSILWIDPD DFPLLVAYWE KTFKIDLFRP QIGVVNVTDA DSVWMEIPDD DDLPTAEELE DWIEDVLSGK INTEDDDEDD DDDDNSDEED NDDSDDDDDE

Target Information

Calsequestrin (CASQ) is a Ca²⁺-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle. The cardiac form (CASQ2) is encoded by a separate gene.
CASQ2 primarily buffers sarcoplasmic reticulum Ca²⁺ ions and also regulates the open probability of ryanodine receptor 2 (RyR2).
Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), which may lead to cardiac arrest.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.