Thermo Fisher Scientific CASQ2 Monoclonal Antibody (1B6)
CASQ2 단백질을 인식하는 고특이성 Mouse 모노클로날 항체로, Western blot 및 ELISA에 적합합니다. 인간 CASQ2 단백질에 반응하며, 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- H00000845-M01
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific CASQ2 Monoclonal Antibody (1B6)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B6 |
| Immunogen | CASQ2 (AAH22288, 20 a.a. approximately 399 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EEGLNFPTYD GKDRVVSLSE KNFKQVLKKY DLLCLYYHEP VSSDKVTQKQ FQLKEIVLEL VAQVLEHKAI GFVMVDAKKE AKLAKKLGFD EEGSLYILKG DRTIEFDGEF AADVLVEFLL DLIEDPVEII SSKLEVQAFE RIEDYIKLIG FFKSEDSEYY KAFEEAAEHF QPYIKFFATF DKGVAKKLSL KMNEVDFYEP FMDEPIAIPN KPYTEEELVE FVKEHQRPTL RRLRPEEMFE TWEDDLNGIH IVAFAEKSDP DGYEFLEILK QVARDNTDNP DLSILWIDPD DFPLLVAYWE KTFKIDLFRP QIGVVNVTDA DSVWMEIPDD DDLPTAEELE DWIEDVLSGK INTEDDDEDD DDDDNSDEED NDDSDDDDDE
Target Information
Calsequestrin (CASQ) is a Ca²⁺-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle. The cardiac form (CASQ2) is encoded by a separate gene.
CASQ2 primarily buffers sarcoplasmic reticulum Ca²⁺ ions and also regulates the open probability of ryanodine receptor 2 (RyR2).
Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), which may lead to cardiac arrest.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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