Thermo Fisher Scientific CASP10 Monoclonal Antibody (3C9)
인간 Caspase-10 단백질을 인식하는 Mouse IgG2a 단일클론 항체. Western blot, ICC/IF, ELISA에 적합. PBS buffer에 보존된 액상 형태로, 보존제 없음. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C9 |
| Immunogen | CASP10 (NP_116756.2, 19–187 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SFREKLLIID SNLGVQDVEN LKFLCIGLVP NKKLEKSSSA SDVFEHLLAE DLLSEEDPFF LAELLYIIRQ KKLLQHLNCT KEEVERLLPT RQRVSLFRNL LYELSEGIDS ENLKDMIFLL KDSLPKTEMT SLSFLAFLEK QGKIDEDNLT CLEDLCKTVV PKLLRNIEK
Target Information
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits (large and small), which dimerize to form the active enzyme.
Caspase-10 cleaves and activates caspases 3 and 7 and is itself processed by caspase 8. Mutations in this gene are associated with apoptosis defects observed in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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