Thermo Fisher Scientific NR3C1 Monoclonal Antibody (OTI4C9), TrueMAB
NR3C1 단백질을 인식하는 Mouse monoclonal antibody (clone OTI4C9). Western blot 및 IHC(P)에서 검증됨. Human 시료에 반응하며, Lyophilized 형태로 제공. PBS buffer(8% trehalose) 기반, -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–265 of human NR3C1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitution: Add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
- For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that functions both as a transcription factor and as a regulator of other transcription factors. It is typically located in the cytoplasm and translocates to the nucleus upon ligand binding.
This receptor is expressed in various heart tissues, including atria, ventricles, aorta, and atrioventricular node.
Alternative splicing and promoter usage lead to multiple transcript variants encoding identical or different isoforms.
Mutations in NR3C1 are associated with glucocorticoid resistance. The receptor forms complexes with chaperone proteins for ligand activation and binds steroids such as dexamethasone with nanomolar affinity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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