Thermo Fisher Scientific CRX Polyclonal Antibody
CRX 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, 인간 시료에 반응. 0.1 mg/mL 농도의 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CRX (Product # RP-97574) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856487 |
Product Specific Information
Immunogen sequence:
PLPEAQRAGL VASGPSLTSA PYAMTYAPAS AFCSSPSAYG SPSSYFSGLD PYLSPMVPQL GGPALSPLSG PSVGPSLAQS PTSLSGQSYG AYSPVDSLEF K
Target Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin. Specifically, CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes.
CRX is also expressed in pinealocytes of the pineal gland and may regulate circadian activity by controlling melatonin synthesis gene expression. CRX(-) mice exhibit disruption of circadian rhythms.
The human CRX gene maps to chromosome 19q13.3 within the cone-rod dystrophy-2 locus (CORD2). Mutations in the CRX gene are implicated in cone-rod dystrophy (CORD), Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP). All characterized CRX mutations produce disease in heterozygotes, though there is no known correlation between phenotype and mutation type. Missense mutations affect the homeobox domain, while frameshift mutations affect the OTX domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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