Thermo Fisher Scientific LIMK1/LIMK2 Polyclonal Antibody
LIMK1/LIMK2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 분석에 적합하며, 고순도(>95%)로 정제됨. 인간, 생쥐, 랫드 반응성. 연구용으로만 사용.
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Applications
- Western Blot (WB): 1:500–1:1,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 500–550 of human LIMK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553813 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 72 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
Proteins containing LIM motifs are typically involved in cell fate determination and growth control.
LIM kinases (LIMK-1 and LIMK-2) regulate F-actin stabilization and cofilin activity, playing roles in cell motility and morphogenesis.
LIMK-1 inhibits neuronal differentiation of PC12 cells by interfering with events downstream of MAPK activation.
Expression patterns of LIMK-1 and LIMK-2 suggest distinct functions during development.
A truncated form of LIMK-2 found in adult testis may arise from an alternative initiation exon.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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