Thermo Fisher Scientific Phospho-HDAC1 (Ser421, Ser423) Polyclonal Antibody
HDAC1 단백질의 Ser421/Ser423 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC 등 다양한 응용에 사용 가능하며, Human, Mouse, Rat 시료에 반응합니다. 항원 친화 크로마토그래피로 정제된 고순도 제품으로 연구용으로 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:200–1:400 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human HDAC1 around the phosphorylation site of Serine 421/423 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553810 |
Product Specific Information
- Detects endogenous HDAC1 protein at approximately 55 kDa.
- Purity >95% by SDS-PAGE.
Target Information
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, are key processes regulating eukaryotic gene expression.
HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex.
It interacts with the retinoblastoma tumor-suppressor protein, playing a critical role in controlling cell proliferation and differentiation.
Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effects on cell growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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