Thermo Fisher Scientific MRVI1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing MRVI1 (CARP) in mouse and bovine samples. Suitable for Western blot and immunocytochemistry. Supplied as liquid whole serum with sodium azide preservative. For research use only.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 93–107 of bovine IRAG |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2170655 |
Product Specific Information
- PA3-851 detects CARP from mouse and bovine samples.
- Successfully used in Western blot and immunocytochemistry procedures.
- Immunogen is a synthetic peptide corresponding to residues 93–107 of bovine IRAG.
Target Information
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, located in the endoplasmic reticulum membrane, is similar to Jaw1, a lymphoid-restricted protein whose expression decreases during lymphoid differentiation.
Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, indicating that this gene may function as a myeloid leukemia tumor suppressor.
Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, some initiating translation at a non-AUG (CUG) start site.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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