Thermo Fisher Scientific Factor XI Monoclonal Antibody (5061)

Applications

Tested Dilution

Publications

Western Blot (WB)

5-10 µg/mL

-

ELISA (ELISA)

5-10 µg/mL

-

Radioimmune Assays (RIA)

5-10 µg/mL

-

Inhibition Assays (IA)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Monoclonal

Type

Antibody

Clone

5061

Immunogen

Human factor XI.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

10.8 mg/mL

Purification

SDS-PAGE

Storage buffer

50% water with 50% glycerol

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1074349

Product Specific Information

MA1-43021 detects Factor XI in human samples.

MA1-43021 has successfully been used in western blot (non-reducing) and radioimmunoassays applications.

MA1-43021 was derived from human factor XI.

Target Information

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.