Thermo Fisher Scientific CD21 Polyclonal Antibody
Thermo Fisher Scientific의 CD21 Polyclonal Antibody는 인간 CD21 단백질을 인식하는 토끼 IgG 항체로, IHC, ICC/IF, Flow Cytometry에 적합합니다. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도, 안정적인 PBS 기반 저장 버퍼를 사용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within Human CD21 aa 984–1033 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2854615 |
Product Specific Information
Positive Control: LOVO, SH-SY5Y, human tonsil tissue, human colon cancer tissue.
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, particularly its breakdown fragments, which remain covalently attached to complement-activating surfaces or antigens. CD21 plays a crucial role in immunocomplex uptake and retention, memory B cell survival, and humoral immune response development. It also acts as a receptor for Epstein-Barr virus and facilitates prion targeting and neuroinvasion. The soluble form (sCD21) retains ligand-binding ability. CD21 interacts with CD23 and associates with CD19, CD81, and Leu13 to form a signal-transduction complex involved in B cell activation. Genetic variations in CD21 are linked to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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