Thermo Fisher Scientific IP6K2 Monoclonal Antibody (OTI1F12), TrueMAB
IP6K2 단백질을 표적하는 Mouse IgG2a 단일클론 항체로, Western blot에 최적화됨. Human, Mouse, Rat 반응성. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도. 연구용으로만 사용 가능.
- 판매단위
- pk
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Thermo Fisher Scientific IP6K2 Monoclonal Antibody (OTI1F12), TrueMAB
Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–250 of human IP6K2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The inositol hexakisphosphate kinase family members IP6K1 and IP6K2 have high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate, converting InsP6 to PP-InsP5.
Neither kinase shows catalytic activity with other inositol pyrophosphates. InsP6 inhibits serine/threonine protein phosphatases and increases calcium influx across the plasma membrane, suggesting a role in insulin exocytosis regulation.
IP6K1 was purified as a 54 kDa protein in rat brain extracts; by homology, IP6K1 and IP6K2 were characterized in mouse as 50 kDa and 49 kDa proteins, respectively. IP6K1 also displays ATP synthase activity, transferring a phosphate from PP-InsP5 to ADP, indicating a potential role as high-energy phosphate donors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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