Thermo Fisher Scientific CD147 (soluble) Monoclonal Antibody (MEM-M6/2)

Applications and Tested Dilutions

View 1 publication

Product Specifications

Product Specific Information

This antibody recognizes the extracellular Ig domain D1 of CD147 (Neurothelin), a 50–60 kDa type I transmembrane glycoprotein primarily expressed on leukocytes, red blood cells, platelets, and endothelial cells. It is not expressed by resting lymphocytes. The antibody exhibits high affinity and can bind to unstimulated peripheral blood T cells.

Target Information

CD147 (also known as basigin, neurothelin, OX-47, 5A11, CE9, M6, EMMPRIN, extracellular matrix metalloproteinase inducer, TCSF, or tumour cell-derived collagenase-stimulatory factor) is a 50–60 kDa glycoprotein with multiple glycosylated forms. It is a plasma membrane protein important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. CD147 belongs to the immunoglobulin superfamily and is highly expressed on metabolically active cells such as lymphoblasts, inflammatory cells, brown adipocytes, and malignant tumor cells. It facilitates cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulates integrin functions, and plays roles in cell development, activation, fetal development, and retinal function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.