Thermo Fisher Scientific CD30 Monoclonal Antibody (MEM-268)

Applications and Tested Dilution

Product Specifications

Additional Formats Available

• Alexa Fluor 647 (MA5-18134)
• Alexa Fluor 700 (MA5-38745)
• APC (MA1-19767)
• FITC (MA1-19765)
• PE (MA1-19766)
• Request custom conjugation

Product Specific Information

This antibody recognizes the extracellular region of CD30 (Ki-1 antigen), a 105 kDa single-chain glycoprotein expressed on Hodgkin’s and Reed-Sternberg cells. It is also found in Burkitt’s lymphomas, virus-infected T and B lymphocytes, and on normal B and T lymphocytes after activation (particularly Th2-type cytokine-producing T cells and CD4+/CD8+ T lymphocytes co-expressing CD45RO and IL4 receptor).

Target Information

CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. It was first identified as a surface antigen of Hodgkin’s and Reed-Sternberg cells using monoclonal antibody Ki-1. Its ligand, CD30L (CD153), mediates cell proliferation, activation, differentiation, and apoptosis through CD30 binding.

CD30 plays a critical role in Hodgkin’s disease and other CD30+ lymphomas and acts as a costimulatory molecule in thymic negative selection. It is expressed in Hodgkin’s lymphoma, Reed-Sternberg cells, and most anaplastic large cell lymphomas (ALCL), as well as in some non-Hodgkin’s lymphomas, virus-infected T/B cells, and activated normal lymphocytes.

The soluble form (sCD30) serves as a marker of Th2 immune response. CD30 interacts with TRAF2 and TRAF5, activating NF-kappaB signaling and regulating apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.