Thermo Fisher Scientific GALR2 Polyclonal Antibody
GALR2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 고농도 액상 형태로 제공되며 장기 보관 시 -20°C 권장. 연구용으로만 사용.
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Thermo Fisher Scientific GALR2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 212–307 of Galanin Receptor 2 (Uniprot ID#O43603) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11153694 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
GalR2 expression has been documented widely in the brain and in peripheral tissues including small intestine, heart, kidney, and liver. Localization data from rat CNS indicate high levels of expression in dorsal root ganglia, amygdala, and Purkinje neurons.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms. Activating ligands induce conformational changes leading to signaling via G-proteins and downstream effectors. Studies also highlight mechanisms of negative regulation of GPCRs, critical for cellular physiological responses and drug development.
Examples of GPCR-targeted pharmaceuticals include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which have major impacts in mental health and allergy treatment markets.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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