Thermo Fisher Scientific IL31RA Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-321 of human IL31RA (NP_0012845011) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IL31RA,uniProtId:Q8NI17-1,ncbiNodeId:9606,antigenRange:20-321,antigenLength:732,antigenImageFileName:PA5-120973_IL31RA_Q8NI17-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120973_IL31RA_Q8NI17-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914545

Product Specific Information

Positive test controls include: Mouse liver, Mouse heart, Mouse brain, Mouse pancreas. The target is usually found in the following locations: Cell membrane, Single-pass type I membrane protein.

Immunogen sequence: VKPVLGIKRM IQIEWIKPEL APVSSDLKYT LRFRTVNSTS WMEVNFAKNR KDKNQTYNLT GLQPFTEYVI ALRCAVKESK FWSDWSQEKM GMTEEEAPCG LELWRVLKPA EADGRRPVRL LWKKARGAPV LEKTLGYNIW YYPESNTNLT ETMNTTNQQL ELHLGGESFW VSMISYNSLG KSPVATLRIP AIQEKSFQCI EVMQACVAED QLVVKWQSSA LDVNTWMIEW FPDVDSEPTT LSWESVSQAT NWTIQQDKLK PFWCYNISVY PMLHDKVGEP YSIQAYAKEG VPSEGPETKV EN

Target Information

IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.