Thermo Fisher Scientific GSK3B Polyclonal Antibody
GSK3B 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, ICC/IF, ELISA, IP에 사용 가능하며, 고순도의 Affinity Chromatography 정제 항체입니다. -20°C에서 보관하며, 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 320–420 of human GSK3β (NP_001139628.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.71 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914547 |
Product Specific Information
- Positive test controls: LO2, HeLa, 22Rv1, U-251MG
- Subcellular localization: Cell membrane, Cytoplasm, Nucleus
Immunogen sequence:
LLEYTPTARL TPLEACAHSF FDELRDPNVK LPNGRDTPAL FNFTTQELSS NPPLATILIP PHARIQAAAS TPTNATAASD ANTGDRGQTN NAASASASNS T
Target Information
GSK3B (Glycogen Synthase Kinase 3 Beta)
GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development, and body pattern formation. It acts as a negative regulator of glucose homeostasis and participates in pathways related to energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptosis.
GSK3B is a key component of the Wnt/β-catenin signaling pathway, mediating β-catenin degradation and inhibiting Wnt signaling. It also functions in the Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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