Thermo Fisher Scientific Desmoglein-3 Monoclonal Antibody (DSG3, 2838)
Desmoglein-3 단백질을 표적하는 Mouse Monoclonal Antibody로, 인간 시료에 반응합니다. IHC 및 Peptide Array에 사용 가능하며, 단백질 A/G로 정제된 액상형 제품입니다. PBS buffer에 보존제 없이 제공되며, 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DSG3, 2838 |
| Immunogen | Recombinant fragment (around aa 379–491) of human DSG3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For immunohistochemistry (PFA-fixed tissues):
- Incubate antibody for 30 minutes at room temperature (RT).
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at RT for 20 minutes.
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is part of the desmosomal cadherin family and plays a key role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium, such as skin, oral mucosa, and esophagus.
Dsg3 is identified as the autoantigen in pemphigus vulgaris (PV), a severe autoimmune disease. Binding of anti-Dsg3 autoantibodies leads to loss of cell adhesion, resulting in blister formation on skin and mucosa and histologically showing suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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