Thermo Fisher Scientific ESCO1 Polyclonal Antibody
Thermo Fisher Scientific의 ESCO1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 ESCO1 단백질을 검출하는 Rabbit IgG 항체입니다. Western blot에 최적화되어 있으며, 고순도(>95%)로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human ESCO1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553947 |
Product Specific Information
This antibody detects endogenous ESCO1 protein with an approximate molecular weight of 95 kDa.
Purity is >95% by SDS-PAGE.
Target Information
EFO1 (Establishment factor-like protein 1), also known as ESCO1 (establishment of cohesion 1 homolog 1) or ESO1, belongs to the acetyltransferase family (GCN5 subfamily).
It is a ubiquitously expressed nuclear protein essential for sister chromatid cohesion.
At its C-terminus, EFO1 contains an H2C2 zinc finger motif and an acetyltransferase domain that exhibits acetyltransferase activity in vivo.
The N-terminus includes two domains similar to alpha- and beta-type linker histone proteins, which are critical for chromosome association.
EFO1 couples cohesion and DNA replication processes, ensuring proper pairing of sister chromatids.
It is phosphorylated during mitosis, potentially regulating its activity.
Alternative splicing results in three known isoforms of EFO1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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