Thermo Fisher Scientific SLC22A4 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:1,000–1:3,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total SLC22A4.

Target Information

Carnitine (β-hydroxy-γ-trimethylaminobutyrate) is a small, highly polar compound that aids in the β-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells.

• OCTN1: Expressed in kidney, trachea, bone marrow, and fetal liver
• OCTN2: Abundantly expressed in kidney, skeletal muscle, placenta, and heart
• OCTN3: Strongly expressed in testis, weakly in kidney

The gene encoding human OCTN1 maps to chromosome 5, and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 lead to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia, and hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.