Thermo Fisher Scientific Phospho-p53 (Ser15) Recombinant Rabbit Monoclonal Antibody (P53S15-1C11), FITC

Thermo Fisher Scientific Phospho-p53 (Ser15) Recombinant Rabbit Monoclonal Antibody (P53S15-1C11), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated: MA5-36927
• APC: MA5-36930
• PE: MA5-36928
• Custom conjugation available on request

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:

• Excellent specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to rabbit immune repertoire

Target Information

The tumor suppressor protein p53 is a transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation.

Key features:

• Regulates genes such as p21waf1 involved in G1 or G2/M arrest
• Contains N-terminal transactivation, central DNA-binding, oligomerisation, and C-terminal regulatory domains
• Phosphorylation at Ser15 is critical for activation and stabilization
• Plays a role in preventing proliferation of damaged cells and acts as an anticancer agent
• Mutations in TP53 are common in human cancers and associated with loss of tumor suppressor activity
• Linked to aging, oxidative stress, and cognitive function deficits

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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