Thermo Fisher Scientific IL-22 Receptor alpha Monoclonal Antibody (305405)
IL-22 Receptor alpha에 특이적인 Mouse IgG1 단일클론 항체로, 인간 시료에 반응합니다. ICC/IF 및 Flow Cytometry에 사용 가능하며, Protein A/G로 정제된 동결건조 형태입니다. PBS + 5% trehalose 버퍼에 보관하며, 연구용으로만 사용됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 8–25 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 2.5 µg per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 305405 |
| Immunogen | CHO-derived recombinant human IL-22 R alpha 1 (Pro18–Thr228) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606659 |
Product Specific Information
In direct ELISAs, no cross-reactivity with recombinant human IL-10, IL-22BP, or IL-20 R alpha is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
A novel cytokine, designated IL-TIF (IL-10 related T cell-derived inducible factor) and IL-22, was recently identified.
The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) belongs to the class II cytokine receptor family.
IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling via the JAK-STAT pathway.
IL22R is expressed in liver and kidney tissues and their cell lines (HepG2, TK-10).
A soluble form of IL-22 receptor (IL-22BP or IL-22RA2) prevents IL-22 binding to the functional receptor complex, neutralizing IL-22 activity.
LPS induces IL-22 expression, indicating its role in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: MA5-24017_IL-22_Receptor_alpha_Q8N6P7-1_House_mouse.svg, MA5-24017_IL-22_Receptor_alpha_Q8N6P7-1_House_mouse_PDP.jpeg)
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