Thermo Fisher Scientific CD101 Monoclonal Antibody (307707)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 2.5 µg per million cells

Product Specifications

Product Specific Information

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

CD101, also known as V7 antigen, is a member of the immunoglobulin superfamily. It forms a disulfide-linked homodimer of unknown function. Expression of CD101 is found on monocytes, granulocytes, and dendritic cells (Langerhans-like cells: HLA-DR, CD1a, CD1c).
It is also expressed on T lymphocytes and plays a role in cell activation. CD101⁺ CD28⁺ cells are highly responsive to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can increase proliferation, suggesting an activating role.

The monoclonal antibody BB27 has been shown to inhibit T cell reactivity in allogeneic and antigen-specific mixed DC-T cell cultures. Mouse CD101 is found on a subpopulation of regulatory T cells (CD4⁺, CD25⁺, Foxp3⁺) with high suppressor activity. Expression of CD101 on human PBMCs stains about 30% of Foxp3⁺ cells, although higher suppressor activity has not been confirmed in humans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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