Thermo Fisher Scientific Bcl-xL Polyclonal Antibody
Bcl-xL 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, IP에 사용 가능. 인간, 마우스, 랫트 등 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. 세포 사멸 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 5 µg | View publication |
| Immunoprecipitation (IP) | 1:50 | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Asp61 of human Bcl-xL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 82.8 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10977568 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other Bcl-2 family members.
Target Information
BCL-XL is a member of the BCL-2 protein family, which forms hetero- or homodimers and acts as anti- or pro-apoptotic regulators involved in various cellular activities.
Located at the outer mitochondrial membrane, BCL-XL regulates VDAC channel opening, mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release — all key factors in apoptosis.
Two alternatively spliced transcript variants encode distinct isoforms: the longer isoform acts as an apoptotic inhibitor, while the shorter form acts as an apoptotic activator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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