Thermo Fisher Scientific Phospho-FADD (Ser194) Polyclonal Antibody
인간 FADD 단백질의 Ser194 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 제품. 연구용으로만 사용 가능하며, 보존제 무첨가 상태로 -20°C 보관.
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Thermo Fisher Scientific Phospho-FADD (Ser194) Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer194 of human FADD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985486 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The FADD protein is an adaptor molecule that interacts with various cell surface receptors and mediates apoptotic signaling. Through its C-terminal death domain, FADD can be recruited by TNFRSF6/Fas-receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, participating in death signaling initiated by these receptors. Interaction with receptors unmasks its N-terminal effector domain, enabling recruitment of caspase-8 and activation of the cysteine protease cascade. Knockout studies in mice indicate its importance in early T cell development.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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