Thermo Fisher Scientific Phospho-Syk (Tyr525, Tyr526) Polyclonal Antibody
인간, 마우스, 랫트에 반응하는 Rabbit Polyclonal 항체로 Tyr525/526 인산화된 Syk 단백질을 검출. Western blot에 적합하며 높은 특이성과 재현성을 제공. 항원 친화 크로마토그래피로 정제된 액상 형태, 보존제 없음, -20°C 보관.
- 카탈로그번호
- PA517811
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-Syk (Tyr525, Tyr526) Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr525/526 of human Syk |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10989209 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other tyrosine-phosphorylated members of the Syk/Zap-70 tyrosine kinase family.
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcepsilonRI) triggering and phosphorylates downstream adaptor proteins, providing docking sites for subsequent signaling pathways such as calcium mobilization, cytoskeleton remodeling, or transcriptional activation.
Syk binds to receptor assemblies through its SH2 domains interacting with ITAM motifs phosphorylated by Src-family kinases, which also activate Syk by phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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