Thermo Fisher Scientific DC-SIGN Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In Western blot applications, this antibody detects a band at approximately 44 kDa.
• A suggested positive control is human placenta lysate.
• PA5-19967 can be used with blocking peptide PEP-0092.

Target Information

This gene encodes a transmembrane receptor, commonly referred to as DC-SIGN, expressed on the surface of dendritic cells and macrophages. The protein plays a key role in the innate immune system by recognizing a wide range of pathogens including parasites and viruses.

The protein structure consists of:

• N-terminal transmembrane domain
• Tandem-repeat neck domain
• C-type lectin carbohydrate recognition domain

The extracellular region mediates both pathogen recognition and cell adhesion by binding carbohydrate ligands on microbial and host cell surfaces. The neck domain enables receptor oligomerization, enhancing ligand binding avidity.

Variations in the neck domain repeat number are rare but significantly affect ligand-binding capacity. DC-SIGN is closely related to L-SIGN (GeneID 10332), with differences in ligand-binding and tissue distribution. Alternative splicing produces multiple isoforms.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.