Thermo Fisher Scientific CRALBP Polyclonal Antibody
Thermo Fisher Scientific의 CRALBP Polyclonal Antibody는 인간 및 마우스 시료에 반응하며, Western blot과 Immunocytochemistry에 적합합니다. 항원 친화 크로마토그래피로 정제된 고품질 항체로 시각 관련 단백질 연구에 유용합니다. 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 74–311 of Human CRALBP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.41 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547233 |
Product Specific Information
- Recommended positive controls: HepG2, mouse eye
- Predicted reactivity: Mouse (91%), Rat (91%), Xenopus laevis (82%), Chicken (86%), Bovine (92%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP).
Genetic mutations involving CRALBP’s lack of function have been linked to visual diseases such as bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy.
The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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