Thermo Fisher Scientific Ki67 Monoclonal Antibody (OTI18G5), TrueMAB
인간 Ki-67 단백질을 인식하는 마우스 단클론 항체로, 세포 증식 마커 분석에 적합합니다. 포르말린 고정 파라핀 절편 조직의 IHC(P)에서 사용 가능하며, 동결건조 형태로 제공됩니다. 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 보장합니다.
- 판매단위
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI18G5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1160–1493 of human MKI67 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | −20°C, avoid freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Ki-67 is a nuclear protein expressed during various stages of the cell cycle, particularly late G1, S, G2, and M phases.
It associates with euchromatin at the perichromosomal layer, centromeric heterochromatin, and nucleolus through its forkhead-associated (FHA) domain.
Ki-67 shows cell cycle–dependent localization: perinucleolar in G1, nuclear matrix in G2, and chromosomal during M phase.
Because it is absent in G0 cells and increases from G1 through mitosis, Ki-67 serves as a reliable proliferation marker.
In neoplastic tissues, the Ki-67 index correlates strongly with tumor grade and is used to assess cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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