Thermo Fisher Scientific TRAF2 Recombinant Rabbit Monoclonal Antibody (12H7L9)

Thermo Fisher Scientific TRAF2 Recombinant Rabbit Monoclonal Antibody (12H7L9)

Applications

• Western Blot (WB): Tested dilution 1:250–1:1000

Species Reactivity

• Human
• Mouse
• Rat

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Horse, Rat, and Pig.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Advantages include:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to large rabbit immune repertoire

Target Information

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are adaptor proteins linking the TNF receptor superfamily to signaling pathways, regulating cell death and stress responses.
TRAF proteins share homology regions enabling receptor binding and activation of signaling cascades.
TRAF2 and TRAF3 bind directly to CD40, essential for NF-κB activation in B lymphocytes.
TRAF2 and TRAF6 are required for CD40 signaling in nonhematopoietic cells.
TRAF2 also interacts with lymphotoxin-beta receptor (LTβR) with TRAF3 and apoptosis inhibitors cIAP1 and Smac.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.