Thermo Fisher Scientific CCR5 Recombinant Rabbit Monoclonal Antibody (2H14L10)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• This antibody is predicted to react with Monkey.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems.
• The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits, followed by screening for optimal clones.
• Advantages include:
  • Better specificity and sensitivity
  • Lot-to-lot consistency
  • Animal origin-free formulations
  • Broader immunoreactivity due to rabbit immune repertoire

Target Information

Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells.
CCR5 is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, facilitating fusion and entry of human white blood cells.
CCR5 is essential for infection by HIV-1, HIV-2, and SIV.
Beta-chemokines RANTES, MIP-alpha, and MIP-beta are ligands for CCR5 and can prevent infection by M-tropic HIV-1.
CCR5 associates with the CD4-gp120 complex of HIV, leading to membrane fusion and virus entry.
The amino-terminal domain and extracellular loops of CCR5 serve as HIV binding sites.
CCR5 mRNA is expressed in lymphoid organs and monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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